|
T9989 |
AChE-IN-27
|
|
Others
|
|
AChE-IN-27 is a small molecule used for high-throughput assays. |
|
T12421 |
PF-04885614
|
|
Sodium Channel
|
|
PF-04885614 is a potent inhibitor of NaV1.8, has potential for neurological and neurodevelopmental diseases treatment. |
|
T8944 |
TTA-A2
|
|
Calcium Channel
|
|
TTA-A2 is a selective T-type calcium channel antagonist as a potent anticonvulsant that the Cav3.1 isoform plays a prominent role in mediating. TTA-A2 is equally potent against the Cav3.1 (a1G) and Cav3.2 (a1H) channels ... |
|
T8930 |
CID44216842
|
KUC103479N-02 |
CDK
,
Ras
|
|
CID44216842 (KUC103479N-02) is a potent Cdc42-selective guanine nucleotide binding lead inhibitor. The EC50s for Cdc42 WT and Cdc42Q61L mutant are 1.0 and 1.2 μM in GTP binding assay, respectively. The EC50s for Cdc42 WT... |
|
T3198L |
PRE-084 hydrochloride
|
|
Sigma receptor
|
|
PRE-084 hydrochloride is a selective agonist of σ1(IC50:44 nM, in the sigma receptor assay). |
|
T25458 |
Golexanolone
|
Golexanolona,Golexanolonum |
|
|
Golexanolone can be used to study neurological diseases. |
|
T14390 |
Azelaprag
|
AMG 986 |
Apelin receptor
|
|
Azelaprag (AMG 986) is an effective small-molecule apelin receptor agonist. Azelaprag can be used to treat neurological diseases and cardiovascular diseases. |
|
T15553 |
Iganidipine
|
NKY 722 |
Calcium Channel
|
|
Iganidipine（NKY 722） is a new water-soluble Ca2+ antagonist with antihypertensive activity for research and neurological related diseases. |
|
T22850 |
ICI 204,448
|
ICI 204448,ICI204448,ICI-204448 |
Opioid Receptor
|
|
ICI 204,448 is a potent κ-opioid agonist with potential analgesic activity for the study of neurological diseases. |
|
T30998L |
COG-1410 acetate
|
COG-1410 acetate(878009-24-6 Free base) |
Apoptosis
|
|
COG-1410 acetate is an apolipoprotein E-derived peptide and can be used in studies about neurological diseases. |
|
T22736 |
DMeOB
|
3,3'-Dimethoxybenzaldazine |
GluR
|
|
DMeOB (3,3'-Dimethoxybenzaldazine) is a negative regulator with mGluR5 agonist activity and can be used to study neurological diseases. |
|
T68143 |
Solpecainol
|
|
Sodium Channel
|
|
solpecainol is a sodium channel blocker used in the study of neurological and cardiovascular diseases. |
|
T60908 |
SARM1-IN-2
|
|
Others
|
|
SARM1-IN-2 is a potent SARM1 inhibitor for the study of metabolic and neurological related diseases. |
|
T17211 |
Vafidemstat
|
ORY-2001 |
Histone Demethylase
,
MAO
|
|
Vafidemstat (ORY-2001) is a selective, orally active lysyl-histone demethylase (LSD1)/MAO-B inhibitor that crosses the blood-brain barrier for the study of neurological diseases. |
|
T2192 |
Indazole
|
|
Sodium Channel
|
|
Indazole is also called benzpyrazole or isoindazone. Its derivatives exhibit a wide range of biological activities. Indazole and its derivatives can be used in the research of cancer, neurological diseases, cardiovascula... |
|
T27830L |
Lifarizine FA
|
Lifarizine FA(119514-66-8 Free base) |
Sodium Channel
|
|
Lifarizine FA is a sodium channel blocker used in the treatment of neurological disorders and cardiovascular diseases, study of stroke. |
|
T67938 |
PROT-IN-1
|
|
Others
|
|
PROT-IN-1 is a potent high-affinity inhibitor of L-proline transporter and a candidate compound for the treatment of neurological diseases. |
|
T9694 |
Emraclidine
|
CVL-231 |
AChR
|
|
Emraclidine (CVL-231) is a muscarinic M4 receptor positive allosteric modulator and can be used in neurological diseases studies. |
|
T40042 |
Evifacotrep
|
|
TRP/TRPV Channel
|
|
Evifacotrep is a short transient receptor potential channel 5 ( TRPC5 ) antagonist (WO2020061162, compound 100). Evifacotrep can be used for the research of neurological diseases. |
|
TP2417 |
Tidembersat
|
|
Others
|
|
Tidembersat is a small molecule compound used to treat and/or prevent degenerative diseases such as Huntington's chorea, schizophrenia, neurological. |
|
T13419 |
ROCK-IN-1
|
|
ROCK
|
|
ROCK-IN-1 is a potent ROCK inhibitor that inhibits ROCK2-mediated signaling with an IC50 value of 1.2 nM.ROCK-IN-1 can be used in the study of neurological disorders and inflammation-related diseases. |
|
T78825 |
D4R agonist-1
|
|
Dopamine Receptor
|
|
D4R agonist-1 is a selective and potent D4R partial agonist (Ki:2.2 nM).D4R agonist-1 can be used to study neurological diseases. |
|
TQ0238 |
Lanabecestat
|
LY3314814,AZD3293 |
BACE
|
|
Lanabecestat (AZD3293) is a highly potent and highly permeable, orally active BACE1 inhibitor (Ki: 0.4 nM) that crosses the blood-brain barrier.Lanabecestat can be used for the study of neurological diseases such as Alzh... |
|
T78650 |
Nrf2 activator-3
|
|
Antioxidant
,
Nrf2
|
|
Nrf2 activator-3 is a potent Nrf2 activator with potential anti-inflammatory, antioxidant and anti-tumor activity, which can be used to study neurological and immune-related diseases. |
|
T71749 |
SF-22
|
|
Neuropeptide Y Receptor
|
|
SF-22 is a neuropeptide Y receptor (Y2R) antagonist that crosses the blood-brain barrier and has potential anti-inflammatory activity for the study of diseases associated with neurological disorders. |
|
T30586L |
Brefonalol HCl
|
Brefonalol HCl(103880-26-8 Free base) |
Adrenergic Receptor
|
|
Brefonalol HCl is an ADRA antagonist used in the treatment of neurological disorders and cardiovascular diseases and can be used in the study of angina pectoris, arrhythmias and hypertension. |
|
T22180 |
3F8
|
3F 8,3F-8 |
GSK-3
|
|
3F8 is a selective GSK-3β inhibitor that can be used as a new tool and potential therapeutic candidate compound for GSK3-related diseases, and can be used in the study of neurological disorders and cancer. |
|
T27918 |
LY 43578
|
LY-43578,LY43578 |
P450
,
Aromatase
|
|
LY 43578 is an orally active aromatase inhibitor. LY43578 could inhibit O-demethylation of P-450-dependent p-nitroanisole and N-demethylation of ethylmorphine (IC50 of 0.3 and 5 μm, respectively) in rat liver microsomes.... |
|
T60796 |
Cholesterol 24-hydroxylase-IN-1
|
|
P450
|
|
Cholesterol 24-hydroxylase-IN-1 is an orally active, selective, and potent inhibitor of cholesterol 24-hydroxylase (CH24H or CYP46A1) that crosses the blood-brain barrier.Cholesterol 24-hydroxylase-IN-1 may be useful in ... |
|
T68073 |
Flosatidil
|
|
Calcium Channel
|
|
Flosatidil is a small molecule voltage-gated calcium channel complex (VDCCs) blocker for the treatment of neurological disorders and cardiovascular diseases, and can be used in the study of angina pectoris. |
|
T78570 |
XE991
|
|
Potassium Channel
|
|
XE991 is a novel and selective Kv7 (KCNQ) channel blocker.XE 991 dihydrochloride inhibits Kv7.1 (KCNQ1), Kv7.2 (KCNQ2), Kv7.2 + Kv7.3 (KCNQ3) channels, and M-current, and can be used for the study of neurological disease... |
|
T111959 |
IFB-088 acetate
|
|
|
|
IFB-088 acetate, a benzyl guanidine derivative, is used to treat diseases and cancers associated with the PPP1R15A pathway and associated with protein misfolding stress, Examples include tau disease, synaptic riboprotein... |
|
T80799 |
WAY-620147
|
|
MAO
|
|
WAY-620147 is a derivative of N-(2-morpholinoethyl)nicotinamide, which is able to inhibit Monoamine Oxidase.WAY-620147 has an IC50 value of 26 μM for MAO-A and 55 μM for MAO-B, and can be used for the study of neurologic... |
|
T14782 |
Brilaroxazine
|
RP5063 |
Dopamine Receptor
,
5-HT Receptor
|
|
Brilaroxazine (RP5063) is a potent multimodal dopamine/5-HT modulator. Brilaroxazine is a partial agonist of dopamine D2, D3, and D4 receptors, 5-HT1A (Ki =1.5 nM) and 5-HT2A (Ki = 2.5 nM), and has antagonist activity 5-... |
|
T0511 |
Tolperisone hydrochloride
|
Muscalm,Midocalm,Tolperisone HCl |
Sodium Channel
|
|
Tolperisone hydrochloride (Muscalm), a centrally acting muscle relaxant, is used in the therapy of pathologically increased tone of the cross-striated muscle resulted by neurological diseases (damage of the encephalomyel... |
|
T77342 |
GSK-3 inhibitor 3
|
|
GSK-3
,
Microtubule Associated
|
|
GSK-3 inhibitor 3 is a selective, orally active, brain-permeable GSK-3 inhibitor that inhibits GSK-3α and GSK-3β with IC50s of 0.35 nM and 0.25 nM, respectively.GSK-3 inhibitor 3 reduces the phosphorylation level of tau ... |
|
T124358 |
Deferoxamine
|
Deferoxamine B,Desferrioxamine B |
Apoptosis
,
Antioxidant
,
HIF
,
Autophagy
|
|
Deferoxamine（Desferrioxamine B） is an iron chelator (binds Fe(III) and many other metal cations) that inhibits neuronopathy, may be used to modify the reduction of iron accumulation and deposition in tissues, and may imp... |
|
T38899 |
Irsenontrine
|
E2027,Irsenontrine |
|
|
Irsenontrine (E2027) is a selective and orally active inhibitor of phosphodiesterase 9 (PDE9), primarily used for researching neurological diseases. |
|
T10911 |
H3 receptor antagonist 1
|
|
Histamine Receptor
|
|
H3 receptor antagonist 1 is used in the study of neurological diseases, histamine H3 receptor antagonist. |
|
T13593 |
Heterocyclyl carbamate derivative 1
|
|
Others
|
|
Heterocyclyl carbamate derivative 1, a heterocyclyl carbamate derivative, is used for the research of neurological diseases and inflammatory. |
|
T19143 |
4-(6-Bromo-2-benzothiazolyl)benzenamine
|
|
Others
|
|
4-(6-Bromo-2-benzothiazolyl)benzenamine is a β-amyloid PET tracer and can be used in the diagnosis of neurological diseases. |
|
T10154 |
MAO-B-IN-1
|
|
Others
|
|
MAO-B-IN-1 is a monoamine oxidase B inhibitor and can be used for the research of neurological diseases. |
|
T39108 |
Irsenontrine maleate
|
E2027 maleate |
|
|
Irsenontrine (E2027) maleate is a selective and orally active inhibitor of phosphodiesterase 9 (PDE9). It can be utilized in the study of neurological diseases. |
|
T39940 |
Plazinemdor
|
|
|
|
Plazinemdor is an NMDA receptor positive allosteric modulator with potential applications in psychiatric, neurological, neurodevelopmental disorders, and diseases of the nervous system. |
|
T32143 |
Imagabalin
|
PD332334,PD 0332334,PD-0332334,PD0332334,PD-332334,PD 332334 |
|
|
Imagabalin is an active compound used in the study of neurological diseases. |
|
T35878 |
N-(3-Aminopropyl)cyclohexylamine
|
|
Others
|
|
N-(3-Aminopropyl)cyclohexylamine, a derivative of cyclohexylamine, functions as a selective and competitive inhibitor of spermine synthase, making it suitable for research on neurological diseases[1]. |
|
T37599 |
DA-JC4
|
DA-JC4 |
|
|
DA-JC4 is a compound with dual GLP-1/GIP receptor agonist properties. It is recommended for use in researching neurological diseases and investigating insulin signaling pathways[1][2][3]. |
|
T63244 |
MG-2119
|
|
|
|
MG-2119 is a potent inhibitor of monomeric tau and α-syn aggregation and can be used to study neurological diseases. |
|
T26622 |
Ampreloxetine
|
TD-9855,TD 9855,TD9855 |
5-HT Receptor
,
Norepinephrine
|
|
Ampreloxetine (TD-9855) is a norepinephrine reuptake inhibitor used to study neurological diseases. |
|
T61744 |
A1/A3 AR antagonist 2
|
|
|
|
The compound is an a1/a3 adenosine receptor antagonist, which helps to treat (neurological) inflammatory diseases. |
